In Crawlers, Serena (Lutz), the overworked and underappreciated manager of the Paradiso Palms apartment complex, discovers a mysterious death. But what begins as a suspected viral outbreak quickly spirals into something far more terrifying: a catastrophic infestation of venomous spiders spreading rapidly through the building. Trapped by a quarantine with no way out, residents are forced into a desperate fight for survival as the threat multiplies by the second. Armed only with her intimate knowledge of the building, Serena may be the only one who can keep them alive — if she can confront her deepest fear.